Female mixed urinary incontinence: a clinical review

JAMA. 2014 May 21;311(19):2007-14. doi: 10.1001/jama.2014.4299.


Importance: Mixed urinary incontinence, a condition of both stress and urge urinary incontinence, is prevalent in 20% to 36% of women and is challenging to diagnosis and treat because urinary symptoms are variable and guidelines for treatment are not clear.

Objective: To review the diagnosis and management of mixed urinary incontinence in women, with a focus on current available evidence.

Evidence review: MEDLINE was searched from January 1, 1992, to December 31, 2013. Additional citations were obtained from references of the selected articles and reviews. Articles that discussed the prevalence, diagnosis, results, and treatment of mixed urinary incontinence were selected for review. Evidence was graded using Oxford Centre for Evidence-Based Medicine levels of evidence for treatment recommendations.

Findings: The MEDLINE search resulted in 785 articles. After selection and obtainment of additional citations, a total of 73 articles were reviewed. There is high-quality (level 1) evidence for treating urinary incontinence with weight loss, for treating stress urinary incontinence by performing anti-incontinence procedures of both traditional and mid-urethral slings and retropubic urethropexies, and for managing urge urinary incontinence with anticholinergic medications. However, direct high-quality evidence for treatment of women with mixed urinary incontinence is lacking, as are clear diagnostic criteria and management guidelines.

Conclusion and relevance: High-quality, level 1 evidence for urinary incontinence therapy can guide clinicians in the treatment of the components of mixed urinary incontinence. Because high-quality evidence is lacking regarding the treatment of mixed urinary incontinence, treatment generally begins with conservative management emphasizing the most bothersome component. Randomized trials in women with mixed urinary incontinence populations are needed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Evidence-Based Medicine
  • Female
  • Humans
  • Middle Aged
  • Practice Guidelines as Topic
  • Urinary Incontinence, Stress / diagnosis*
  • Urinary Incontinence, Stress / epidemiology
  • Urinary Incontinence, Stress / therapy*
  • Urinary Incontinence, Urge / diagnosis*
  • Urinary Incontinence, Urge / epidemiology
  • Urinary Incontinence, Urge / therapy*