Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 20 (3), 251-67

Ferrous Iron Uptake by Bifidobacterium Breve

Affiliations

Ferrous Iron Uptake by Bifidobacterium Breve

A Bezkorovainy et al. Biol Trace Elem Res.

Abstract

Bifidobacterium breve transports ferrous iron in preference to the ferric form in a saturable, concentration-dependent manner with an optimum pH of 6. Iron transport is highly temperature sensitive. Two transport systems with apparent Km's of 86 +/- 27 and 35 +/- 20 microM (p greater than 0.01) were distinguished, one operating at high iron concentrations, the other at low iron concentrations. Iron uptake could not be accounted for by surface binding. Uptake of iron was inhibited by iron chelators, a protein ionophore, and ATPase inhibitors, and it was stimulated by potassium ionophores. The presence of a ferri reductase in the insoluble cell fraction of B. breve and its "spent" growth medium was demonstrated. The hypothesis is presented that iron uptake by bifidobacteria is related to the nutritional immunity phenomenon.

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

References

    1. J Med Microbiol. 1976 Aug;9(3):335-44 - PubMed
    1. Microbios. 1978;22(87):35-43 - PubMed
    1. Am J Clin Nutr. 1977 Nov;30(11):1799-810 - PubMed
    1. Microbiol Immunol. 1984;28(9):975-86 - PubMed
    1. Am J Clin Nutr. 1980 Nov;33(11 Suppl):2434-9 - PubMed

LinkOut - more resources

Feedback