Neuroimaging findings in sickle cell disease

Br J Radiol. 2014 Aug;87(1040):20130699. doi: 10.1259/bjr.20130699. Epub 2014 May 21.


At least 25% of individuals with sickle cell disease will have a neurological complication over their lifetime, often as early as in childhood. Neuroradiological findings in patients with sickle cell disease are common and include acute territorial infarction, silent ischaemia and intracranial haemorrhage. Imaging abnormalities are typically, but not always, manifestations of the underlying vasculopathy. Coexisting acute and chronic pathology may pose challenges to interpretation.

Publication types

  • Review

MeSH terms

  • Anemia, Sickle Cell / complications*
  • Brain Diseases / diagnosis
  • Brain Diseases / etiology
  • Central Nervous System Diseases / diagnosis*
  • Central Nervous System Diseases / etiology*
  • Humans
  • Neuroimaging / methods*