Common bile-duct mucosa in choledochoduodenostomy patients--histological and histochemical study

HPB Surg. 1988 Sep;1(1):15-20. doi: 10.1155/1988/85102.


We describe the histological and histochemical changes of the common bile-duct mucosa in specimens obtained by means of peroral cholangioscopy, 1-12 years after choledochoduodenal anastomosis. Our findings--hyperplasia of the superficial epithelium, metaplastic goblet cells containing predominantly acid sialomucins, and pyloric-like gland formation containing neutral mucins--express a morphological and functional differentiation of the common bile-duct mucosa that probably facilitates its survival in a different environment. We consider that these adaptive changes may explain the uneventful long-term postoperative period of choledochoduodenostomized patients.

MeSH terms

  • Choledochostomy*
  • Common Bile Duct / chemistry
  • Common Bile Duct / pathology*
  • Epithelium / pathology
  • Humans
  • Mucins / chemistry
  • Mucous Membrane / chemistry
  • Mucous Membrane / pathology
  • Sialomucins
  • Staining and Labeling


  • Mucins
  • Sialomucins