[Conformational regulation of integrin activation in drug discovery]

MeSH terms

• Autoimmune Diseases / drug therapy
• Autoimmune Diseases / genetics
• Cell Adhesion / genetics
• Cell Adhesion Molecules
• Cell Movement / genetics
• Chemotaxis, Leukocyte / genetics
• Drug Discovery*
• Extracellular Matrix / metabolism
• Humans
• Inflammation / drug therapy
• Inflammation / genetics
• Inflammation / immunology*
• Integrins* / antagonists & inhibitors
• Integrins* / chemistry
• Integrins* / genetics
• Integrins* / physiology
• Leukocytes / immunology*
• Ligands
• Membrane Proteins / metabolism
• Molecular Conformation
• Molecular Targeted Therapy
• Mutation
• Neoplasms / drug therapy
• Neoplasms / genetics
• Protein Structure, Tertiary
• Signal Transduction / physiology
• Thrombosis / drug therapy
• Thrombosis / genetics