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. 2014 Jul 1;24(13):2797-801.
doi: 10.1016/j.bmcl.2014.04.117. Epub 2014 May 9.

Sulfonamide Inhibition Studies of the β Carbonic Anhydrase From Drosophila Melanogaster

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Sulfonamide Inhibition Studies of the β Carbonic Anhydrase From Drosophila Melanogaster

Leo Syrjänen et al. Bioorg Med Chem Lett. .

Abstract

An inibition study of the β-carbonic anhydrase (CA, EC 4.2.1.1) DmBCA from the insect Drosophila melanogaster with sulfonamides and sulfamates is reported. Among the panel of 40 investigated compounds, the best DmBCA inhibitors were the sulfonylated benzenesulfonamides and ethoxzolamide, which showed inhibition constants in the range of 65.3-138 nM. Methazolamide and sulthiame were also effective inhibitors with KIs ranging between 237 and 249 nM, whereas most of the simple aromatic/heterocyclic sulfonamides showed inhibition constants in the range of 0.47-6.40 μM. Topiramate, zonisamide and saccharine did not inhibit DmBCA. As orthologs of this mitochondrial CA are found in many insect species involved in the spread of various diseases, inhibitors interfering with their activity may be of interest for developing insecticides with an alternative mechanism of action to the presently used agents, for which many insects developed extensive resistance.

Keywords: Carbonic anhydrase; Drosophila melanogaster; Enzyme inhibitor; Sulfonamide; β-Class enzyme.

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