Severe spruelike enteropathy due to olmesartan

Rev Esp Enferm Dig. 2014 Feb;106(2):142-4. doi: 10.4321/s1130-01082014000200011.


Villous atrophy and negative serologic testing is a diagnostic challenge, and the rarer possibility of drug-induced enteritis should be considered. We report a rare case of severe spruelike enteritis due to olmesartan that completely resolved after withdrawal of the drug. The possibility that patient labeled as "refractory" celiac disease may actually be due to drug treatment should always be taken into consideration, to avoid unnecessary investigations.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiotensin II Type 1 Receptor Blockers / adverse effects*
  • Angiotensin II Type 1 Receptor Blockers / therapeutic use
  • Celiac Disease / chemically induced*
  • Celiac Disease / pathology
  • Humans
  • Imidazoles / adverse effects*
  • Imidazoles / therapeutic use
  • Intestinal Mucosa / pathology
  • Male
  • Tetrazoles / adverse effects*
  • Tetrazoles / therapeutic use


  • Angiotensin II Type 1 Receptor Blockers
  • Imidazoles
  • Tetrazoles
  • olmesartan