A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis

J Sci Food Agric. 2015 Mar 15;95(4):702-7. doi: 10.1002/jsfa.6752. Epub 2014 Jun 24.


Background: Recent studies show that enzymatically hydrolysed collagen, the collagen peptide, is absorbed and distributed to joint tissues and has analgesic and anti-inflammatory properties. A double-blind, placebo-controlled, randomised trial with collagen peptides isolated from pork skin (PCP) and bovine bone (BCP) sources was carried out to study the effectiveness of orally supplemented collagen peptide to control the progression of osteoarthritis in patients diagnosed with knee osteoarthritis. Improvement in treatment was assessed with reduction in Western Ontario McMaster Universities (WOMAC), visual analogue scale (VAS) and quality of life (QOL) scores from baseline to 13 weeks (Visit 7). Safety and tolerability were also evaluated.

Results: There was significant reduction from baseline to Visit 7 in the primary end points of WOMAC and VAS scores and in the secondary end point of QOL score in subjects with PCP and BCP groups, while in subjects with placebo group the end point indices remained unaltered. Furthermore, all the score levels of WOMAC, VAS and QOL decreased significantly (P < 0.01) in the study group compared to placebo group in Visit 7.

Conclusion: The study demonstrated that collagen peptides are potential therapeutic agents as nutritional supplements for the management of osteoarthritis and maintenance of joint health.

Keywords: cartilage; clinical study; collagen peptide; osteoarthritis.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Bone and Bones / chemistry
  • Cattle
  • Collagen / adverse effects
  • Collagen / chemistry
  • Collagen / therapeutic use*
  • Combined Modality Therapy / adverse effects
  • Dietary Supplements* / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / diet therapy*
  • Osteoarthritis, Knee / immunology
  • Osteoarthritis, Knee / physiopathology
  • Osteoarthritis, Knee / therapy
  • Patient Dropouts
  • Peptide Fragments / adverse effects
  • Peptide Fragments / chemistry
  • Peptide Fragments / therapeutic use*
  • Quality of Life
  • Severity of Illness Index
  • Skin / chemistry


  • Anti-Inflammatory Agents, Non-Steroidal
  • Peptide Fragments
  • Collagen

Associated data

  • CTRI/CTRI/2009/091/000993