Parasite load decrease during application of a safe and easily applied antileishmanial aminoglycoside cream

Afif Ben Salah; Amor Zaâtour; Nathalie Ben Messaoud; Abdelhamid Kidar; Philip L Smith; Karen M Kopydlowski; Mara Kreishman-Deitrick; Carl J Nielsen; Anne Novitt-Moreno; Janet H Ransom; Gloria Morizot; Max Grogl; Pierre A Buffet

doi:10.1371/journal.pntd.0002749

Parasite load decrease during application of a safe and easily applied antileishmanial aminoglycoside cream

PLoS Negl Trop Dis. 2014 May 22;8(5):e2749. doi: 10.1371/journal.pntd.0002749. eCollection 2014 May.

Affiliations

¹ Institut Pasteur de Tunis, Tunis, Tunisia.
² Regional Hospital of Gafsa, Gafsa, Tunisia.
³ United States Army Medical Materiel Development Activity, Fort Detrick, Maryland, United States of America.
⁴ Fast-Track Drugs & Biologics, LLC, North Potomac, Maryland, United States of America.
⁵ Assistance Publique - Hôpitaux de Paris, Paris, France.
⁶ Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.

No abstract available

Publication types

Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Administration, Topical
Adolescent
Adult
Aged
Dermis / parasitology
Drug Combinations
Female
Gentamicins / administration & dosage*
Humans
Leishmania donovani / drug effects*
Leishmaniasis, Visceral / drug therapy*
Leishmaniasis, Visceral / parasitology*
Male
Middle Aged
Parasite Load
Paromomycin / administration & dosage*
Trypanocidal Agents / administration & dosage*
Trypanocidal Agents / adverse effects
Young Adult

Substances

Drug Combinations
Gentamicins
Trypanocidal Agents
Paromomycin

Grants and funding

This study was funded by the US Army Medical Materiel Development Activity, US Army Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.