Thrombophilia in patients with retinal vein occlusion: a retrospective analysis

Ophthalmologica. 2014;232(1):46-52. doi: 10.1159/000360013. Epub 2014 May 16.


Background: To assess the prevalence of thrombophilia in patients with central (CRVO) and branch retinal vein occlusion (BRVO).

Methods: In 139 patients with CRVO (n = 88) and BRVO (n = 51) and in 40 healthy controls factor VIII, fibrinogen, antithrombin III, protein C, protein S, activated protein C resistance, anticardiolipin antibodies (ACA), homocysteine, factor V Leiden, prothrombin G20210A and methylene tetrahydrofolate reductase (MTHFR) C677T mutation were assessed retrospectively.

Results: Elevated factor VIII activity and the homozygous MTHFR C677T mutation were significantly more often found in CRVO and BRVO cases compared to controls. Age-, gender- and C-reactive protein-adjusted logistic regression analysis did not show a significant additive effect of elevated factor VIII activity on the risk of developing CRVO/BRVO. Elevated fibrinogen levels and ACA were significantly more often found in CRVO than amongst controls. No significant differences were found concerning the remaining variables.

Conclusions: We suggest elevated fibrinogen levels, ACA and the homozygous MTHFR C677T mutation as potential risk factors for CRVO/BRVO.

MeSH terms

  • Aged
  • Antibodies, Anticardiolipin / blood
  • Biomarkers / metabolism
  • Female
  • Fibrinogen
  • Humans
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Middle Aged
  • Mutation
  • Prevalence
  • Retinal Vein Occlusion / complications*
  • Retinal Vein Occlusion / diagnosis
  • Retrospective Studies
  • Risk Factors
  • Thrombophilia / blood
  • Thrombophilia / etiology*


  • Antibodies, Anticardiolipin
  • Biomarkers
  • Fibrinogen
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)