A new sesquiterpene from the Hainan gorgonian Menella kanisa Grassoff

Nat Prod Res. 2014;28(15):1147-51. doi: 10.1080/14786419.2014.918122. Epub 2014 May 23.

Abstract

Chemical investigation of the gorgonian Menella kanisa Grassoff collected from the South China Sea led to the isolation of a new sesquiterpene, menecubebane A (1), together with three known compounds, 8-methoxy-trans-calamenene (2), 8,9-dihydro-linderazulene (3) and (3β)-oleanan-3-ol (4). The structure of 1 was determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. All the compounds were evaluated for their cytotoxic, brine shrimp lethal and antifouling activities.

Keywords: Menella kanisa Grassoff; gorgonian; sesquiterpene; structure elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Artemia / drug effects
  • Biofouling / prevention & control
  • China
  • Drug Screening Assays, Antitumor
  • Female
  • HCT116 Cells
  • Hep G2 Cells
  • Humans
  • Male
  • Oceans and Seas
  • Prostatic Neoplasms
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • Sesquiterpenes
  • menecubebane A