Background: The birth prevalence of cerebral palsy varies over time among very preterm infants, and the reasons are poorly understood.
Objective: To describe the variation in the prevalence of cerebral palsy among very preterm infants over time, and to relate these differences to other maternal or neonatal factors.
Methods: A population-based cohort of very preterm infants was evaluated over a 20-year period (1988 to 2007) divided into four equal epochs.
Results: The prevalence of cerebral palsy peaked in the third epoch (1998 to 2002) while mortality rate peaked in the second epoch (1993 to 1997). Maternal anemia, tocolytic use and neonatal need for home oxygen were highest in the third epoch.
Conclusions: Lower mortality rates did not correlate well with the prevalence of cerebral palsy. Maternal risk factors, anemia and tocolytic use, and the newborn need for home oxygen were highest during the same epoch as the peak prevalence of cerebral palsy.
Keywords: Cerebral palsy; Infant; Population-based; Premature.
Preterm Premature Rupture of Membranes at 22-25 Weeks' Gestation: Perinatal and 2-year Outcomes Within a National Population-Based Study (EPIPAGE-2)E Lorthe et al. Am J Obstet Gynecol 219 (3), 298.e1-298.e14. PMID 29852153.Preterm premature rupture of membranes at 22-25 weeks is associated with high incidence of mortality and morbidity, with wide variations by gestational age at preterm pre …
Changes in Neurodevelopmental Outcomes at 18 to 22 Months' Corrected Age Among Infants of Less Than 25 Weeks' Gestational Age Born in 1993-1999SR Hintz et al. Pediatrics 115 (6), 1645-51. PMID 15930228.Early childhood neurodevelopmental outcomes among infants of <25 weeks' EGA are not improving in the postsurfactant era, despite more aggressive perinatal and neonatal …
Increasing Prevalence of Cerebral Palsy Among Very Preterm Infants: A Population-Based StudyMJ Vincer et al. Pediatrics 118 (6), e1621-6. PMID 17074842.Cerebral palsy has increased substantially among very preterm infants in association with and possibly as a consequence of large declines in infant mortality.
Oxytocin Receptor Antagonists for Inhibiting Preterm LabourV Flenady et al. Cochrane Database Syst Rev (6), CD004452. PMID 24903678. - ReviewThis review did not demonstrate superiority of ORA (largely atosiban) as a tocolytic agent compared with placebo, betamimetics or CCB (largely nifedipine) in terms of pre …
Effects of Targeting Lower Versus Higher Arterial Oxygen Saturations on Death or Disability in Preterm InfantsLM Askie et al. Cochrane Database Syst Rev 4 (4), CD011190. PMID 28398697. - ReviewIn extremely preterm infants, targeting lower (85% to 89%) SpO₂ compared to higher (91% to 95%) SpO₂ had no significant effect on the composite outcome of death or major …
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Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships Between Registry Characteristics and Knowledge DisseminationDS Hurley et al. Int J Phys Med Rehabil 3 (2). PMID 27790626.Literature searches returned 177 articles meeting inclusion criteria. The majority (69%) of registry/surveillance program productivity was related to contributions as a R …