Mechanisms and functions of inflammasomes

Cell. 2014 May 22;157(5):1013-22. doi: 10.1016/j.cell.2014.04.007.


Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18. Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering pyroptosis, a proinflammatory and lytic mode of cell death. The therapeutic potential of inhibiting these proinflammatory caspases in infectious and autoimmune diseases is raised by the successful deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant inflammasome signaling. This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy
  • Cell Death
  • Humans
  • Infections / immunology
  • Infections / microbiology
  • Inflammasomes / immunology*
  • Inflammasomes / metabolism
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation / therapy
  • Interleukin-1 / immunology
  • Interleukin-11 / immunology


  • Adaptor Proteins, Signal Transducing
  • Inflammasomes
  • Interleukin-1
  • Interleukin-11