Sixth INTERMACS annual report: a 10,000-patient database

James K Kirklin; David C Naftel; Francis D Pagani; Robert L Kormos; Lynne W Stevenson; Elizabeth D Blume; Marissa A Miller; J T Baldwin; James B Young

doi:10.1016/j.healun.2014.04.010

Sixth INTERMACS annual report: a 10,000-patient database

J Heart Lung Transplant. 2014 Jun;33(6):555-64. doi: 10.1016/j.healun.2014.04.010. Epub 2014 Apr 21.

Authors

James K Kirklin¹, David C Naftel², Francis D Pagani³, Robert L Kormos⁴, Lynne W Stevenson⁵, Elizabeth D Blume⁶, Marissa A Miller⁷, J T Baldwin⁷, James B Young⁸

Affiliations

¹ Department of Surgery, University of Alabama at Birmingham, Alabama. Electronic address: jkirklin@uab.edu.
² Department of Surgery, University of Alabama at Birmingham, Alabama.
³ Department of Surgery, University of Michigan, Ann Arbor, Michigan.
⁴ Department of Surgery, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania.
⁵ Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts.
⁶ Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
⁷ Division of Cardiovascular Diseases, Advanced Technologies and Surgery Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.
⁸ Department of Medicine, Cleveland Clinic Foundation Lerner College of Medicine, Cleveland, Ohio.

PMID: 24856259
DOI: 10.1016/j.healun.2014.04.010

Abstract

The sixth annual report of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) summarizes the first 8 years of patient enrollment. The analysis is based on data from >10,000 patients and updates demographics, survival, adverse events and risk factors. Among patients with continuous-flow pumps, actuarial survival continues to be 80% at 1 year and 70% at 2 years. The report features a comparison of two eras of continuous-flow durable devices in the USA in terms of device strategy, patient profiles, adverse event burden, survival and quality of life.

Keywords: INTERMACS; advanced heart failure; destination therapy; mechanical support; ventricular assist device.

MeSH terms

Adolescent
Adult
Child
Child, Preschool
Databases, Factual*
Extracorporeal Circulation / adverse effects
Extracorporeal Circulation / instrumentation
Extracorporeal Circulation / statistics & numerical data
Female
Heart Failure / therapy*
Heart-Assist Devices / adverse effects
Heart-Assist Devices / statistics & numerical data*
Humans
Infant
Male
Quality of Life
Survival Analysis
United States