A new Lycopodium alkaloid from Phlegmariurus fargesii

Chin J Nat Med. 2014 May;12(5):373-6. doi: 10.1016/S1875-5364(14)60046-7.

Abstract

Aim: To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii.

Method: Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectroscopic methods and chemical correlation. The acetylcholinesterase (AChE) inhibitory activity of the isolated compounds was evaluated.

Results: A new Lycopodium alkaloid, lycopodine N-oxide (1), along with lycopodine (2), 8,15-dehydrolycopodine (3), 6α-hydroxylycopodine (4), deacetyllycoclavine (5), N-methylhuperzine B (6), lycodine (7), and phlegmarine (8), was isolated.

Conclusion: Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Other alkaloids are isolated from this plant for the first time.

Keywords: Lycopodine N-oxide; Lycopodium alkaloids; Phlegmariurus fargesii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Huperzia / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Quinolizines / chemistry*
  • Quinolizines / isolation & purification

Substances

  • Alkaloids
  • Plant Extracts
  • Quinolizines
  • lycopodine