Multifunctional tunable p(inulin) microgels

Mater Sci Eng C Mater Biol Appl. 2014 Jul 1:40:366-72. doi: 10.1016/j.msec.2014.04.028. Epub 2014 Apr 16.

Abstract

Inulin, inulin-silica and modified inulin microgels were prepared in a single step via crosslinking within microemulsion, and used as drug delivery devices. Inulin-silica composite micro particles were also synthesized in the presence of tetraethyl orthosilicate (TEOS) via a water-in-oil microemulsion polymerization/crosslinking technique. To generate porous inulin particles, inulin-silica particles were treated with 0.5M NaOH solution to dissolve silica particles. Furthermore, virgin inulin (p(inulin)) and porous inulin microgels (por-p(inulin)) were quaternized successfully by treatment with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTMAC) in aqueous solution, generating positive charges on the biopolymer as q-p(inulin). Rosmarinic acid (RA) was used as model drug for loading and release studies by synthesized inulin-based microgels in phosphate buffer solution (PBS) at pH7.4. It was shown that the absorption and release rate are influenced by zeta potential and porosity of the microgels.

Keywords: Modified inulin microgel/nanogel; Natural polymeric microgel; P(inulin) microgel; Porous p(inulin) microgel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Cinnamates / chemistry
  • Cinnamates / metabolism
  • Depsides / chemistry
  • Depsides / metabolism
  • Drug Carriers / chemistry*
  • Gels / chemical synthesis
  • Gels / chemistry*
  • Inulin / chemistry*
  • Nitrogen / chemistry
  • Porosity
  • Rosmarinic Acid
  • Silicon Dioxide / chemistry*

Substances

  • Cinnamates
  • Depsides
  • Drug Carriers
  • Gels
  • Silicon Dioxide
  • Inulin
  • Nitrogen