Surface charge switching nanoparticles for magnetic resonance imaging

Int J Pharm. 2014 Aug 25;471(1-2):127-34. doi: 10.1016/j.ijpharm.2014.05.029. Epub 2014 May 22.

Abstract

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

Keywords: Fe(3)O(4); Magnetic resonance imaging (MRI); Surface charge switching nanoparticle; pH-Responsive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Deoxycholic Acid / analogs & derivatives*
  • Deoxycholic Acid / chemistry
  • Female
  • Flow Cytometry
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetite Nanoparticles / chemistry*
  • Mice, Nude
  • Microscopy, Confocal
  • Microscopy, Fluorescence
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology
  • Particle Size
  • Polylysine / chemistry*
  • Static Electricity
  • Surface Properties

Substances

  • Contrast Media
  • Magnetite Nanoparticles
  • deoxycholic acid-b-poly(Lys-2,3-dimethylmaleic acid)
  • Deoxycholic Acid
  • Polylysine