Comparative studies of doxorubicin and 4'-epidoxorubicin effects on cardiovascular system in rabbits

Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):597-609.

Abstract

4'-epidoxorubicin (4'-epiDXR) was compared with doxorubicin (DXR) for myocardial effects in rabbits. Histologically, both drugs when given for six weeks induced a high incidence of diffused myocardial damage. The myocardial damage was less evident in rabbits treated with 4'-epiDXR than DXR for 3 weeks. Functionally 4'-epiDXR like DXR significantly reduced cardiac index (CI), stroke index (SI) and mean arterial blood pressure (MAP).

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Cardiovascular System / drug effects*
  • Deslanoside / pharmacology
  • Doxorubicin / pharmacology*
  • Epirubicin / pharmacology*
  • Female
  • Heart Rate / drug effects
  • In Vitro Techniques
  • Male
  • Myocardium / pathology
  • Rabbits
  • Stroke Volume / drug effects

Substances

  • Epirubicin
  • Doxorubicin
  • Deslanoside