Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M Malebo; Stephan A Jonker; Reiner Waibel; Mayunga H H Nkunya

doi:10.1007/s13659-014-0010-x

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Nat Prod Bioprospect. 2014 Apr;4(2):101-5. doi: 10.1007/s13659-014-0010-x. Epub 2014 Apr 2.

Authors

Hamisi M Malebo¹, Stephan A Jonker², Reiner Waibel³, Mayunga H H Nkunya²

Affiliations

¹ Department of Traditional Medicine Research, National Institute for Medical Research, P.O. Box 9653, Dar es Salaam, Tanzania.
² Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.
³ Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany.

Abstract

New hexalobine type alkaloid, 5-(2″,3″-epoxy-3″-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl)indole (1) alongside the known hexalobines 3-(2',3'-dihydroxy-3'-methylbutyl)-5-(3″-methylcrotonoyl) indole (2), 3,5-hexalobine C (3) and 3,5-hexalobine D (4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

Keywords: Candida albicans; Hexalobines; Hexalobus monopetalus; Indole alkaloids.