The first case of acinic cell carcinoma of the breast within a fibroadenoma: case report

Int J Surg. 2014:12 Suppl 1:S232-5. doi: 10.1016/j.ijsu.2014.05.005. Epub 2014 May 22.

Abstract

A case of acinic cell carcinoma of the breast is reported in a 26-year-old woman. She presented a lump in her right breast, that seemed to be a fibroadenoma. The open biopsy revealed a well-bordered fibroadenoma, together with a proliferation of cells characterized by serous acinar differentiation and eosinophilic cytoplasmic granules. Tumor cells stained for amylase, lysozyme, α-1-antichymotripsin, epithelial membrane antigen, S-100 protein, pan-cytokeratin, cytokeratin 7 and E-cadherin. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 overexpression, CD10, P63, smooth muscle actin, cytokeratin 5/6 were negative. The sentinel node was negative. 8 months after surgery she is in good clinical conditions without recurrence or metastases.

Keywords: Acinic cell carcinoma; Breast cancer; Eosinophilic cytoplasmic granules.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / surgery
  • Carcinoma, Acinar Cell / diagnosis*
  • Carcinoma, Acinar Cell / surgery
  • Diagnosis, Differential
  • Female
  • Fibroadenoma / diagnosis*
  • Fibroadenoma / surgery
  • Follow-Up Studies
  • Humans
  • Mastectomy
  • Neoplasms, Multiple Primary*
  • Ultrasonography, Mammary