Risk of coronary artery disease in patients with systemic sclerosis: a systematic review and meta-analysis

Clin Rheumatol. 2014 Aug;33(8):1099-104. doi: 10.1007/s10067-014-2681-4. Epub 2014 May 25.


Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been shown to increase coronary artery disease (CAD) risk but the data on systemic sclerosis (SSc) is unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing CAD risk in patients with SSc versus non-SSc participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random effect, generic inverse variance method. Four studies were identified and included in our data analysis. The pooled risk ratio of CAD in patients with SSc was 1.82 (95 % CI, 1.40 to 2.36). The statistical heterogeneity of this meta-analysis was moderate with an I (2) of 73 %. Our study demonstrated a statistically significant increased CAD risk among patients with SSc.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Coronary Artery Disease / etiology*
  • Humans
  • Risk
  • Scleroderma, Systemic / complications*