In a five year period 73 cases of pemphigus vulgaris (PV) and 94 of bullous pemphigoid (BP) were studied to investigate important parameters for these diseases. From the results it was found that the incidence of PV was higher in women whereas that of BP was almost equal in both sexes. The incidence of PV was highest in the sixth decade but was highest in the eighth decade for BP. Indirect immunofluorescence (IIF) was more sensitive in PV whereas direct immunofluorescence (DIF) was more sensitive in BP. The present study provides a basis for comparison with results of previous or future studies in Greek and other populations.