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Comparative Study
. 2014;2014:595479.
doi: 10.1155/2014/595479. Epub 2014 Apr 17.

Effect of Dietary Intake of Avocado Oil and Olive Oil on Biochemical Markers of Liver Function in Sucrose-Fed Rats

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Free PMC article
Comparative Study

Effect of Dietary Intake of Avocado Oil and Olive Oil on Biochemical Markers of Liver Function in Sucrose-Fed Rats

Octavio Carvajal-Zarrabal et al. Biomed Res Int. .
Free PMC article

Abstract

Metabolic changes, along with cardiovascular and hepatic factors, are associated with the development of diseases such as diabetes, dyslipidemia, and obesity. We evaluated the effect of avocado oil supplementation (centrifuged and solvent extracted), compared with olive oil, upon the hepatic function in sucrose-fed rats. Twenty-five rats were divided into five groups: control (basal diet), a sucrose-fed group (basal diet plus 30% sucrose solution), and three other groups (S-OO, S-AOC, and S-AOS, indicating basal diet plus 30% sucrose solution plus olive oil OO, avocado oil extracted by centrifugation AOC or using solvent AOS, resp.). Glucose, total cholesterol, triglycerides, total protein, albumin, globulin, direct bilirubin, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, alkaline phosphatase, cholinesterase, and α -amylase concentrations were determined and avocado oil effect on them was studied. In some cases the induced metabolic alteration significantly affected total protein and bilirubin levels and also had a highly significant effect on α -amylase levels. AOC and AOS exhibited effects similar to those of olive oil, according to the nonsignificant difference in fatty acid profile observed by other authors. Avocado oil consumption could be beneficial in the control of altered metabolic profile illnesses as it presents effects on hepatic function biochemical markers similar to olive oil.

Figures

Figure 1
Figure 1
Blood serum profile levels of liver function markers in rats fed with different oil diets: a) total protein; b) albumin; c) globulin; d) direct bilirubin. Corn-canola diet plus 30% sucrose in drinking water (S group, n = 5); olive oil diet plus 30% sucrose in drinking water (S-OO group, n = 5); avocado oil diet extracted by centrifugation plus 30% sucrose in drinking water (S-AOC group, n = 5); avocado oil diet extracted by solvent plus 30% sucrose in drinking water (S-AOS group, n = 5). Values are mean ± SD. *P < 0.05; **P < 0.01 versus corresponding data in CG group.
Figure 2
Figure 2
Blood serum profile levels of liver function markers in rats fed with different oil diets: a) GOT; b) GPT; c) Alkaline phosphatase; d) Cholinesterase; e) α-amylase. Corn-canola diet (CG group, n = 5); corn-canola diet plus 30% sucrose in drinking water (S group, n = 5); olive oil diet plus 30% sucrose in drinking water (S-OO group, n = 5); avocado oil diet extracted by centrifugation plus 30% sucrose in drinking water (S-AOC group, n = 5); avocado oil diet extracted by solvent plus 30% sucrose in drinking water (S-AOS group, n = 5). GOT: glutamic oxaloacetic transaminase; GPT: glutamic pyruvic transaminase. Values are mean ± SD. *P < 0.05; **P < 0.01 versus corresponding data in CG group.

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