This paper is an overview of the literature concerning the "know how" of the GlideScope® use in adults. We summarized the main evidences of the last 10 years with particular attention to experts' suggestions about clinical practice of the GlideScope®, noticing matters still debated on GlideScope® use. We used PubMed to search publications from January 2003 to June 2013 using the search terms "GlideScope", "video laryngoscope" and "videolaryngoscopy". These publications were searched manually or references to further publication not identified using PubMed. All works that made a point worth including were cited in the discussion. Our research confirms the value of GlideScope® use in airway management and highlights the debate about the use of videolaryngoscopes in routine cases and the operators who may use them in clinical practice.