Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;166(5):667-76.
doi: 10.1111/bjh.12935. Epub 2014 May 23.

Body Size and Multiple Myeloma Mortality: A Pooled Analysis of 20 Prospective Studies

Free PMC article

Body Size and Multiple Myeloma Mortality: A Pooled Analysis of 20 Prospective Studies

Lauren R Teras et al. Br J Haematol. .
Free PMC article


Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m(2) ) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m(2) ) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

Keywords: and anthropometry; body mass index; multiple myeloma; pooled analysis; prospective cohort study.

Similar articles

  • Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies.
    Genkinger JM, Kitahara CM, Bernstein L, Berrington de Gonzalez A, Brotzman M, Elena JW, Giles GG, Hartge P, Singh PN, Stolzenberg-Solomon RZ, Weiderpass E, Adami HO, Anderson KE, Beane-Freeman LE, Buring JE, Fraser GE, Fuchs CS, Gapstur SM, Gaziano JM, Helzlsouer KJ, Lacey JV Jr, Linet MS, Liu JJ, Park Y, Peters U, Purdue MP, Robien K, Schairer C, Sesso HD, Visvanathan K, White E, Wolk A, Wolpin BM, Zeleniuch-Jacquotte A, Jacobs EJ. Genkinger JM, et al. Ann Oncol. 2015 Nov;26(11):2257-66. doi: 10.1093/annonc/mdv355. Epub 2015 Sep 7. Ann Oncol. 2015. PMID: 26347100 Free PMC article. Review.
  • Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies.
    Campbell PT, Newton CC, Kitahara CM, Patel AV, Hartge P, Koshiol J, McGlynn KA, Adami HO, Berrington de González A, Beane Freeman LE, Bernstein L, Buring JE, Freedman ND, Gao YT, Giles GG, Gunter MJ, Jenab M, Liao LM, Milne RL, Robien K, Sandler DP, Schairer C, Sesso HD, Shu XO, Weiderpass E, Wolk A, Xiang YB, Zeleniuch-Jacquotte A, Zheng W, Gapstur SM. Campbell PT, et al. Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):597-606. doi: 10.1158/1055-9965.EPI-16-0796. Epub 2017 Mar 17. Cancer Epidemiol Biomarkers Prev. 2017. PMID: 28314823 Free PMC article. Clinical Trial.
  • Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.
    Kitahara CM, McCullough ML, Franceschi S, Rinaldi S, Wolk A, Neta G, Olov Adami H, Anderson K, Andreotti G, Beane Freeman LE, Bernstein L, Buring JE, Clavel-Chapelon F, De Roo LA, Gao YT, Gaziano JM, Giles GG, Håkansson N, Horn-Ross PL, Kirsh VA, Linet MS, MacInnis RJ, Orsini N, Park Y, Patel AV, Purdue MP, Riboli E, Robien K, Rohan T, Sandler DP, Schairer C, Schneider AB, Sesso HD, Shu XO, Singh PN, van den Brandt PA, Ward E, Weiderpass E, White E, Xiang YB, Zeleniuch-Jacquotte A, Zheng W, Hartge P, Berrington de González A. Kitahara CM, et al. Thyroid. 2016 Feb;26(2):306-18. doi: 10.1089/thy.2015.0319. Thyroid. 2016. PMID: 26756356 Free PMC article.
  • Multiple Myeloma Mortality in Relation to Obesity Among African Americans.
    Sonderman JS, Bethea TN, Kitahara CM, Patel AV, Harvey C, Knutsen SF, Park Y, Park SY, Fraser GE, Teras LR, Purdue MP, Stolzenberg-Solomon RZ, Gillanders EM, Palmer JR, Kolonel LN, Blot WJ. Sonderman JS, et al. J Natl Cancer Inst. 2016 May 4;108(10):djw120. doi: 10.1093/jnci/djw120. Print 2016 Oct. J Natl Cancer Inst. 2016. PMID: 27147231 Free PMC article.
  • Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies.
    Wallin A, Larsson SC. Wallin A, et al. Eur J Cancer. 2011 Jul;47(11):1606-15. doi: 10.1016/j.ejca.2011.01.020. Epub 2011 Feb 25. Eur J Cancer. 2011. PMID: 21354783 Review.
See all similar articles

Cited by 26 articles

See all "Cited by" articles

Publication types