Delphinol® standardized maqui berry extract reduces postprandial blood glucose increase in individuals with impaired glucose regulation by novel mechanism of sodium glucose cotransporter inhibition

Panminerva Med. 2014 Jun;56(2 Suppl 3):1-7.


Aim: The impetus of our study was to investigate the effects of a nutritional supplement Delphinol®, an extract of maqui berries (Aristotelia chilensis) standardised to ≥25% delphinidins and ≥35% total anthocyanins, on postprandial blood glucose and insulin levels and identify the physiologic mechanism involved.

Methods: Postprandial blood glucose and insulin were investigated in double-blind, placebo-controlled, cross-over fashion in ten volunteers with moderate glucose intolerance. Longer term effects on blood sugar levels were investigated in streptozotocin-diabetic rats over a four months period. Effects of maqui berry delphinidins on sodium-glucose symport were examined in rodent jejenum of the small intestine.

Results: Delphinol® intake prior to rice consumption statistical significantly lowered post prandial blood glucose and insulin as compared to placebo. We identified an inhibition of Na+-dependant glucose transport by delphinidin, the principal polyphenol to which Delphinol® is standardised. In a diabetic rat model the daily oral application of Delphinol® over a period of four months significantly lowered fasting blood glucose levels and reached values indistinguishable from healthy non-diabetic rats.

Conclusion: Our results suggest a potential use of Delphinol® for naturally controlling post-prandial blood glucose owed to inhibition of sodium glucose co-transporter in small intestine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Anthocyanins / analysis
  • Anthocyanins / therapeutic use
  • Biomarkers / blood
  • Blood Glucose / drug effects*
  • Blood Glucose / metabolism
  • Chile
  • Cross-Over Studies
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / diagnosis
  • Diabetes Mellitus, Experimental / drug therapy
  • Double-Blind Method
  • Elaeocarpaceae* / chemistry
  • Female
  • Fruit
  • Glucose Intolerance / blood
  • Glucose Intolerance / diagnosis
  • Glucose Intolerance / drug therapy*
  • Humans
  • Hypoglycemic Agents / adverse effects
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / blood
  • Jejunum / drug effects*
  • Jejunum / metabolism
  • Male
  • Mice, Inbred C57BL
  • Phytotherapy
  • Plant Extracts / adverse effects
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal
  • Postprandial Period
  • Rats
  • Rats, Sprague-Dawley
  • Sodium-Glucose Transport Proteins / antagonists & inhibitors*
  • Sodium-Glucose Transport Proteins / metabolism
  • Time Factors
  • Treatment Outcome


  • Anthocyanins
  • Biomarkers
  • Blood Glucose
  • Delphinol
  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts
  • Sodium-Glucose Transport Proteins
  • delphinidin