Technical tips for collagenase injection treatment for Dupuytren contracture

Roy A Meals; Vincent R Hentz

doi:10.1016/j.jhsa.2014.03.016

Technical tips for collagenase injection treatment for Dupuytren contracture

J Hand Surg Am. 2014 Jun;39(6):1195-200.e2. doi: 10.1016/j.jhsa.2014.03.016.

Authors

Roy A Meals¹, Vincent R Hentz²

Affiliations

¹ Department of Orthopedic Surgery, University of California at Los Angeles; Department of Plastic Surgery, Stanford University, Stanford, CA. Electronic address: rmeals@ucla.edu.
² Department of Orthopedic Surgery, University of California at Los Angeles; Department of Plastic Surgery, Stanford University, Stanford, CA.

PMID: 24862115
DOI: 10.1016/j.jhsa.2014.03.016

Abstract

We describe technical tips for injecting collagenase into Dupuytren cords based on experience acquired during the prerelease Food and Drug Administration clinical trials and with subsequent clinical practice. These tips include techniques for extracting the reconstituted enzyme efficiently from the vial, injecting the cord(s) with increased safety to the tendons, and anesthetizing the hand before manipulation. The tips are intended to supplement but by no means replace the manufacturer's prescribing information and training video.

Keywords: Dupuytren; collagenase; injection; technique.

MeSH terms

Clostridium histolyticum / enzymology*
Dupuytren Contracture / drug therapy*
Humans
Injections, Intralesional
Microbial Collagenase / administration & dosage*
Treatment Outcome
United States
United States Food and Drug Administration

Substances

Microbial Collagenase