Calmodulin regulation (calmodulation) of voltage-gated calcium channels

Manu Ben-Johny; David T Yue

doi:10.1085/jgp.201311153

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

J Gen Physiol. 2014 Jun;143(6):679-92. doi: 10.1085/jgp.201311153.

Authors

Manu Ben-Johny¹, David T Yue²

Affiliations

¹ Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
² Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 dyue@jhmi.edu.

Abstract

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca(2+) sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca(2+) signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca(2+) feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Calcium / metabolism*
Calcium Channels, L-Type / metabolism*
Calcium Signaling / physiology*
Calmodulin / metabolism*
Cell Membrane / metabolism*
Humans
Ion Channel Gating / physiology*
Membrane Potentials / physiology*

Substances

Calcium Channels, L-Type
Calmodulin
Calcium

Abstract

Publication types

MeSH terms

Substances

Grant support