Calmodulin regulation (calmodulation) of voltage-gated calcium channels

J Gen Physiol. 2014 Jun;143(6):679-92. doi: 10.1085/jgp.201311153.


Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca(2+) sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca(2+) signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca(2+) feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels, L-Type / metabolism*
  • Calcium Signaling / physiology*
  • Calmodulin / metabolism*
  • Cell Membrane / metabolism*
  • Humans
  • Ion Channel Gating / physiology*
  • Membrane Potentials / physiology*


  • Calcium Channels, L-Type
  • Calmodulin
  • Calcium