Genome-scale Neurogenetics: Methodology and Meaning

Nat Neurosci. 2014 Jun;17(6):756-63. doi: 10.1038/nn.3716. Epub 2014 May 27.

Abstract

Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease / genetics
  • Genome-Wide Association Study / methods
  • Genome-Wide Association Study / trends
  • Genomics*
  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / genetics*
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / genetics*
  • Neurosciences / methods*
  • Neurosciences / trends