Ibrutinib resistance in chronic lymphocytic leukemia

N Engl J Med. 2014 Jun 12;370(24):2352-4. doi: 10.1056/NEJMc1402716. Epub 2014 May 28.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Middle Aged
  • Phosphorylation
  • Point Mutation*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / chemistry
  • Protein-Tyrosine Kinases / metabolism
  • Pyrazoles / metabolism
  • Pyrazoles / therapeutic use*
  • Pyrimidines / metabolism
  • Pyrimidines / therapeutic use*
  • Receptors, Antigen, B-Cell / metabolism
  • Recurrence
  • Sequence Analysis, DNA

Substances

  • PCI 32765
  • Pyrazoles
  • Pyrimidines
  • Receptors, Antigen, B-Cell
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase