[Thyroid hormone and skeletal metabolism]

Clin Calcium. 2014 Jun;24(6):821-7.
[Article in Japanese]


The role of the hypothalamic-pituitary-thyroid axis is important in normal skeletal development, gain of bone mass, and regulation of adult bone metabolism. Hypothyroidism in childhood causes delayed bone maturation and growth disturbance and thyroid dysfunction in adult induces altered bone remodeling and an increased risk of bone fracture. Thyroid hormone actions in skeletal cells are mainly mediated by thyroid hormone receptor α (TRα) . The responses to thyroid hormone are regulated by type 2 and 3 iodothyronine deiodinase (DIO2 and DIO3) , which convert prohormone (T4) to active hormone (T3) . Euthyroid status is necessary for the homeostasis of human bone metabolism.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bone Density
  • Bone Development / physiology*
  • Bone Diseases, Developmental / etiology
  • Bone Remodeling
  • Bone and Bones / metabolism*
  • Child
  • Drug Combinations
  • Fractures, Bone / etiology
  • Humans
  • Hypothyroidism / complications
  • Iodide Peroxidase / physiology
  • Mice
  • Signal Transduction
  • Thyroid Hormone Receptors alpha / physiology
  • Thyroid Hormones / physiology*
  • Thyroxine
  • Triiodothyronine


  • Drug Combinations
  • Thyroid Hormone Receptors alpha
  • Thyroid Hormones
  • Triiodothyronine
  • thyroxine, triiodothyronine drug combination
  • iodothyronine deiodinase type II
  • iodothyronine deiodinase type III
  • Iodide Peroxidase
  • Thyroxine