Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun;52(6):515-20.
doi: 10.1007/s12275-014-4012-5. Epub 2014 May 29.

Superinfection Exclusion Reveals Heteroimmunity Between Pseudomonas Aeruginosa Temperate Phages

Affiliations

Superinfection Exclusion Reveals Heteroimmunity Between Pseudomonas Aeruginosa Temperate Phages

In-Young Chung et al. J Microbiol. .

Abstract

Temperate siphophages (MP29, MP42, and MP48) were isolated from the culture supernatant of clinical Pseudomonas aeruginosa isolates. The complete nucleotide sequences and annotation of the phage genomes revealed the overall synteny to the known temperate P. aeruginosa phages such as MP22, D3112, and DMS3. Genome-level sequence analysis showed the conservation of both ends of the linear genome and the divergence at the previously identified dissimilarity regions (R1 to R9). Protein sequence alignment of the c repressor (ORF1) of each phage enabled us to divide the six phages into two groups: D3112 group (D3112, MP29, MP42, and MP48) and MP22 group (MP22 and DMS3). Superinfection exclusion was observed between the phages belonging to the same group, which was mediated by the specific interaction between the c repressor and the cognate operator. Based on these, we suggest that the temperate siphophages prevalent in the clinical strains of P. aeruginosa represent at least two distinct heteroimmunity groups.

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Bacteriophage. 2011 Jan;1(1):31-45 - PubMed
    1. Environ Microbiol. 2004 Jan;6(1):1-11 - PubMed
    1. Microbiology. 2007 Sep;153(Pt 9):2885-95 - PubMed
    1. Environ Microbiol. 1999 Oct;1(5):421-30 - PubMed
    1. Antimicrob Agents Chemother. 2012 Nov;56(11):5612-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback