Current approaches to enhance CNS delivery of drugs across the brain barriers

Int J Nanomedicine. 2014 May 10;9:2241-57. doi: 10.2147/IJN.S61288. eCollection 2014.

Abstract

Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood-brain barrier and the blood-cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed.

Keywords: blood–brain barrier (BBB); brain-targeted therapy; central nervous system; cerebrospinal fluid (CSF); drug delivery system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood-Brain Barrier / drug effects*
  • Blood-Brain Barrier / metabolism*
  • Central Nervous System Agents / administration & dosage*
  • Central Nervous System Agents / pharmacokinetics*
  • Drug Design
  • Humans
  • Molecular Targeted Therapy / methods*
  • Nanocapsules / administration & dosage*
  • Nanocapsules / chemistry*

Substances

  • Central Nervous System Agents
  • Nanocapsules