Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

doi:10.4103/2225-4110.124355

. 2014 Jan;4(1):72-4.

doi: 10.4103/2225-4110.124355.

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

Mie Nishimura¹, Tatsuya Ohkawara², Hiroji Sato³, Hiroshi Takeda⁴, Jun Nishihira⁵

Affiliations

¹ Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Section of Research and Development, Hokkaido Food Industry Promotion Organization, Sapporo, Japan.
² Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
³ Section of Research and Development, Hokushin Foods, Co. Ltd, Ebetsu, Japan.
⁴ Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
⁵ Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan.

PMID: 24872936
PMCID: PMC4032845
DOI: 10.4103/2225-4110.124355

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

Mie Nishimura et al. J Tradit Complement Med. 2014 Jan.

. 2014 Jan;4(1):72-4.

doi: 10.4103/2225-4110.124355.

Authors

Mie Nishimura¹, Tatsuya Ohkawara², Hiroji Sato³, Hiroshi Takeda⁴, Jun Nishihira⁵

Affiliations

¹ Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Section of Research and Development, Hokkaido Food Industry Promotion Organization, Sapporo, Japan.
² Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
³ Section of Research and Development, Hokushin Foods, Co. Ltd, Ebetsu, Japan.
⁴ Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
⁵ Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan.

PMID: 24872936
PMCID: PMC4032845
DOI: 10.4103/2225-4110.124355

Abstract

The pumpkin seed oil obtained from Cucurbita pepo has been shown to be useful for the treatment of nocturia in patients with urinal disorders in several western countries. In this study, we evaluated the effect of the pumpkin seed oil from Cucurbita maxima on urinary dysfunction in human overactive bladder (OAB). Forty-five subjects were enrolled in this study. An extract of pumpkin seed oil from C. maxima (10 g of oil/day) was orally administrated for 12 weeks. After 6 and 12 weeks, urinary function was evaluated using Overactive Bladder Symptom Score (OABSS). Pumpkin seed oil from C. maxima significantly reduced the degree of OABSS in the subjects. The results from our study suggest that pumpkin seed oil extracts from C. maxima as well as from C. pepo are effective for urinary disorders such as OAB in humans.

Keywords: Cucurbita maxima; Overactive bladder; Pumpkin seed oil.

PubMed Disclaimer

Cited by

Medicinal plants and natural products for treating overactive bladder.
Chen H, Hoi MPM, Lee SMY. Chen H, et al. Chin Med. 2024 Mar 27;19(1):56. doi: 10.1186/s13020-024-00884-3. Chin Med. 2024. PMID: 38532487 Free PMC article. Review.
Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Villadsen AB, Holm-Jacobsen JN, Prabhala BK, Bundgaard-Nielsen C, Huntjens P, Kornum JB, Glavind K, Leutscher PDC, Christensen LP, Jeppesen PB, Sørensen S, Arenholt LTS. Villadsen AB, et al. Nutrients. 2023 Sep 27;15(19):4165. doi: 10.3390/nu15194165. Nutrients. 2023. PMID: 37836449 Free PMC article. Clinical Trial.
LC-MS Metabolomic Profiling of Five Types of Unrefined, Cold-Pressed Seed Oils to Identify Markers to Determine Oil Authenticity and to Test for Oil Adulteration.
Sumara A, Stachniuk A, Trzpil A, Bartoszek A, Montowska M, Fornal E. Sumara A, et al. Molecules. 2023 Jun 14;28(12):4754. doi: 10.3390/molecules28124754. Molecules. 2023. PMID: 37375308 Free PMC article.
Phytosterols in hull-less pumpkin seed oil, rich in ∆⁷-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats.
Kang XC, Chen T, Zhou JL, Shen PY, Dai SH, Gao CQ, Zhang JY, Xiong XY, Liu DB. Kang XC, et al. Food Nutr Res. 2021 Dec 2;65. doi: 10.29219/fnr.v65.7537. eCollection 2021. Food Nutr Res. 2021. PMID: 34984064 Free PMC article.
Pumpkin Seed Oil: An Alternative Medicine.
Shaban A, Sahu RP. Shaban A, et al. Int J Pharmacogn Phytochem Res. 2017;9(2):11. doi: 10.25258/phyto.v9i2.8066. Epub 2017 Feb 25. Int J Pharmacogn Phytochem Res. 2017. PMID: 34924730 Free PMC article.

See all "Cited by" articles

References

1. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21:167–78. - PubMed
1. Abrams P, Kelleher CJ, Kerr LA, Rogers RG. Overactive bladder significantly affects quality of life. Am J Manag Care. 2000;6(Suppl 11):S580–90. - PubMed
1. Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, et al. Impact of nocturia on bonefracture and mortality in older individuals: A Japanese longitudinal cohort study. J Urol. 2010;184:1413–8. - PubMed
1. Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome: Overactive bladder symptom score. Urology. 2006;68:318–23. - PubMed
1. Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients. Forsch Komplementarmed Klass Naturheilkd. 2000;7:200–4. - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

[1] Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21:167–78. - PubMed

[2] Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21:167–78. - PubMed

[3] Abrams P, Kelleher CJ, Kerr LA, Rogers RG. Overactive bladder significantly affects quality of life. Am J Manag Care. 2000;6(Suppl 11):S580–90. - PubMed

[4] Abrams P, Kelleher CJ, Kerr LA, Rogers RG. Overactive bladder significantly affects quality of life. Am J Manag Care. 2000;6(Suppl 11):S580–90. - PubMed

[5] Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, et al. Impact of nocturia on bonefracture and mortality in older individuals: A Japanese longitudinal cohort study. J Urol. 2010;184:1413–8. - PubMed

[6] Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, et al. Impact of nocturia on bonefracture and mortality in older individuals: A Japanese longitudinal cohort study. J Urol. 2010;184:1413–8. - PubMed

[7] Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome: Overactive bladder symptom score. Urology. 2006;68:318–23. - PubMed

[8] Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome: Overactive bladder symptom score. Urology. 2006;68:318–23. - PubMed

[9] Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients. Forsch Komplementarmed Klass Naturheilkd. 2000;7:200–4. - PubMed

[10] Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients. Forsch Komplementarmed Klass Naturheilkd. 2000;7:200–4. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

Affiliations

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

Authors

Affiliations

Abstract

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources