Comparative Genomic Analysis of Two Multidrug-Resistant Clinical Isolates of ST395 Epidemic Strain of Pseudomonas aeruginosa Obtained 12 Years Apart

Benoit Valot; Laurence Rohmer; Michael A Jacobs; Samuel I Miller; Xavier Bertrand; Didier Hocquet

doi:10.1128/genomeA.00515-14

Comparative Genomic Analysis of Two Multidrug-Resistant Clinical Isolates of ST395 Epidemic Strain of Pseudomonas aeruginosa Obtained 12 Years Apart

Genome Announc. 2014 May 29;2(3):e00515-14. doi: 10.1128/genomeA.00515-14.

Authors

Benoit Valot¹, Laurence Rohmer², Michael A Jacobs², Samuel I Miller³, Xavier Bertrand, Didier Hocquet⁴

Affiliations

¹ UMR 6249 CNRS Chrono-environnement, Université de Franche-Comté, Besançon, France.
² Department of Microbiology, University of Washington, Seattle, Washington, USA.
³ Department of Genome Sciences, Immunology, Medicine, University of Washington, Seattle, Washington, USA.
⁴ dhocquet@chu-besancon.fr.

Abstract

Pseudomonas aeruginosa can cause large and prolonged outbreaks in hospitals. We have sequenced and annotated the genomes of two multidrug-resistant P. aeruginosa isolates from the same strain obtained 12 years apart from different patients. Genomic analysis provided insight on the genes acquired and lost by P. aeruginosa during its spread.