Resource utilisation associated with single digit Dupuytren's contracture treated with either surgery or injection of collagenase Clostridium histolyticum

Hand Surg. 2014;19(2):205-9. doi: 10.1142/S021881041450021X.

Abstract

The gold standard treatment for Dupuytren's contracture is surgical excision of the cord. A non-surgical treatment with collagenase clostridium histolyticum injection is available but appears costly.

Objectives: To provide data on resource consumption related to surgical and non-surgical treatment for Dupuytren's contracture.

Design and participants: Twenty patients with a single digit Dupuytren's contracture, 10 treated with surgical excision, and 10 treated with a single injection of collagenase.

Measurements: Minutes spent in theatre, number of follow-up appointments, time to skin healing, and patients return to normal activities of daily living.

Results: The injection group was significantly better regarding theatre time (p < 0.0001), follow-up appointments (p = 0.048), skin healing time (p < 0.001), and return to normal activities of daily living (p = 0.02) than the operated group.

Conclusions: There are significant personal and health economic differences between the two methods of treatment which may influence local choice.

Publication types

  • Comparative Study

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Ambulatory Surgical Procedures / economics
  • Ambulatory Surgical Procedures / statistics & numerical data*
  • Cost of Illness
  • Dupuytren Contracture / economics*
  • Dupuytren Contracture / therapy*
  • Female
  • Humans
  • Injections
  • Male
  • Microbial Collagenase / administration & dosage
  • Microbial Collagenase / economics*
  • Middle Aged
  • National Health Programs
  • Office Visits / economics
  • Office Visits / statistics & numerical data
  • Recovery of Function
  • Return to Work
  • Time Factors
  • United Kingdom
  • Wound Healing

Substances

  • Microbial Collagenase