Decrease of muscle volume in chronic kidney disease: the role of mitochondria in skeletal muscle

Kidney Int. 2014 Jun;85(6):1258-60. doi: 10.1038/ki.2013.539.


Reduced muscle volume and impaired exercise endurance are well-documented phenomena in chronic kidney disease, and the relevant molecular mechanisms have been gradually unveiled. Tamaki et al. demonstrate a reduction of mitochondria content in skeletal muscles as a novel mechanism of reduced exercise endurance in renal insufficiency. In addition, they show that a high-protein diet reduces exercise endurance through an inhibition of muscle pyruvate dehydrogenase.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dietary Proteins / adverse effects*
  • Exercise Tolerance*
  • Male
  • Mitochondria, Muscle / enzymology*
  • Mitochondrial Turnover*
  • Muscle, Skeletal / enzymology*
  • Pyruvate Dehydrogenase Complex / metabolism*
  • Renal Insufficiency, Chronic / enzymology*


  • Dietary Proteins
  • Pyruvate Dehydrogenase Complex