Cargo recognition and trafficking in selective autophagy

Nat Cell Biol. 2014 Jun;16(6):495-501. doi: 10.1038/ncb2979.


Selective autophagy is a quality control pathway through which cellular components are sequestered into double-membrane vesicles and delivered to specific intracellular compartments. This process requires autophagy receptors that link cargo to growing autophagosomal membranes. Selective autophagy is also implicated in various membrane trafficking events. Here we discuss the current view on how cargo selection and transport are achieved during selective autophagy, and point out molecular mechanisms that are congruent between autophagy and vesicle trafficking pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Humans
  • Intracellular Membranes / metabolism*
  • Protein Transport
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Transport Vesicles / metabolism*


  • Receptors, Cytoplasmic and Nuclear