A centrosomal route for cancer genome instability

Nat Cell Biol. 2014 Jun;16(6):504-6. doi: 10.1038/ncb2978.


Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.

Publication types

  • Comment

MeSH terms

  • Animals
  • Centrosome / metabolism*
  • Chromosome Segregation*
  • Cyclin B2 / metabolism*
  • Female
  • Male
  • Tumor Suppressor Protein p53 / metabolism*


  • Ccnb2 protein, mouse
  • Cyclin B2
  • Tumor Suppressor Protein p53