Cadherin adhesion controlled by cortical actin dynamics

Nat Cell Biol. 2014 Jun;16(6):508-10. doi: 10.1038/ncb2980.


Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of cadherin molecules and increase their concentration at junctions.

Publication types

  • Comment

MeSH terms

  • Actins / metabolism*
  • Adherens Junctions / metabolism*
  • Animals
  • Cadherins / genetics*
  • Cadherins / metabolism*
  • Cell Adhesion*
  • Mechanotransduction, Cellular*
  • Sarcoma 180 / metabolism*


  • Actins
  • Cadherins