Phase-contrast microscopy at high x-ray energy with a laboratory setup

Opt Lett. 2014 Jun 1;39(11):3332-5. doi: 10.1364/OL.39.003332.


We report on the design and realization of an x-ray imaging system for quantitative phase-contrast microscopy at high x-ray energy with laboratory-scale instrumentation. Phase and amplitude were separated quantitatively at x-ray energies up to 80 keV with micrometric spatial resolution. The accuracy of the results was tested against numerical simulations, and the spatial resolution was experimentally quantified by measuring a Siemens star phase object. This simple setup should find broad application in those areas of x-ray imaging where high energy and spatial resolution are simultaneously required and in those difficult cases where the sample contains materials with similar x-ray absorption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Microscopy, Phase-Contrast / instrumentation*
  • Microscopy, Phase-Contrast / methods
  • Optical Phenomena
  • X-Rays