ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation

Mediators Inflamm. 2014;2014:649718. doi: 10.1155/2014/649718. Epub 2014 Apr 28.

Abstract

ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADAM Proteins / physiology*
  • ADAMTS Proteins
  • Animals
  • Arthritis / enzymology*
  • Arthritis, Rheumatoid / enzymology
  • Gene Expression Regulation, Enzymologic*
  • Gonads / pathology
  • Humans
  • Inflammation / enzymology*
  • Metalloproteases / physiology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred DBA
  • Mice, Knockout
  • Osteoarthritis / enzymology
  • Protein Structure, Tertiary
  • Schizophrenia / enzymology
  • Trophoblasts / pathology

Substances

  • Metalloproteases
  • ADAM Proteins
  • ADAMTS Proteins
  • ADAMTS12 protein, human
  • Adamts12 protein, mouse