Ceftriaxone-induced hemolytic anemia: case report and review of literature

J Pediatr Hematol Oncol. 2015 Jan;37(1):e63-6. doi: 10.1097/MPH.0000000000000181.


Ceftriaxone is a frequently used empiric antibiotic in children. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with a high mortality rate. A 14-year-old boy suffering from Crohn disease developed bacterial pneumonia that was treated with ceftriaxone. We report successful management of ceftriaxone-induced hemolytic anemia (CIHA) in this patient and review the CIHA literature in pediatric patients. Early recognition of CIHA with prompt discontinuation of ceftriaxone therapy may have a beneficial role in reduction of high mortality seen in these patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Anemia, Hemolytic / chemically induced*
  • Anemia, Hemolytic / therapy
  • Anti-Bacterial Agents / adverse effects*
  • Ceftriaxone / adverse effects*
  • Humans
  • Male


  • Anti-Bacterial Agents
  • Ceftriaxone