Defining the radiobiology of prostate cancer progression: An important question in translational prostate cancer research

Exp Biol Med (Maywood). 2014 Jul;239(7):805-812. doi: 10.1177/1535370214536669. Epub 2014 May 30.


Prostate cancer is one of the most common malignancies affecting men worldwide. High mortality rates from advanced and metastatic prostate cancer in the United States are contrasted by a relatively indolent course in the majority of cases. This gives hope for finding methods that could direct personalized diagnostic, preventative, and treatment approaches to patients with prostate cancer. Recent advances in multiparametric magnetic resonance imaging (MP-MRI) offer a noninvasive diagnostic intervention which allows correlation of prostate tumor image characteristics with underlying biologic evidence of tumor progression. The power of MP-MRI includes examination of both local invasion and nodal disease and might overcome the challenges of analyzing the multifocal nature of prostate cancer. Future directions include a careful analysis of the genomic signature of individual prostatic lesions utilizing image-guided biopsies. This review examines the diagnostic potential of MRI in prostate cancer.

Keywords: Prostate cancer; image-guided biopsy; lymph node imaging; magnetic resonance imaging; radiobiology.