Third-degree heart block associated with lyme carditis: review of published cases

Clin Infect Dis. 2014 Oct;59(7):996-1000. doi: 10.1093/cid/ciu411. Epub 2014 May 30.


Lyme carditis is an uncommon manifestation of Lyme disease that most commonly involves some degree of atrioventricular conduction blockade. Third-degree conduction block is the most severe form and can be fatal if untreated. Systematic review of the medical literature identified 45 published cases of third-degree conduction block associated with Lyme carditis in the United States. Median patient age was 32 years, 84% of patients were male, and 39% required temporary pacing. Recognizing patient groups more likely to develop third-degree heart block associated with Lyme carditis is essential to providing prompt and appropriate therapy.

Keywords: Lyme carditis; Lyme disease; atrioventricular conduction block; heart block.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Demography
  • Female
  • Heart Block / epidemiology*
  • Heart Block / etiology*
  • Humans
  • Lyme Disease / complications*
  • Lyme Disease / epidemiology
  • Male
  • Middle Aged
  • Myocarditis / complications*
  • Myocarditis / epidemiology
  • United States / epidemiology
  • Young Adult