Antiviral potential of lactic acid bacteria and their bacteriocins

Probiotics Antimicrob Proteins. 2014 Dec;6(3-4):177-85. doi: 10.1007/s12602-014-9162-6.


Emerging resistance to antiviral agents is a growing public health concern worldwide as it was reported for respiratory, sexually transmitted and enteric viruses. Therefore, there is a growing demand for new, unconventional antiviral agents which may serve as an alternative to the currently used drugs. Meanwhile, published literature continues shedding the light on the potency of lactic acid bacteria (LAB) and their bacteriocins as antiviral agents. Health-promoting LAB probiotics may exert their antiviral activity by (1) direct probiotic-virus interaction; (2) production of antiviral inhibitory metabolites; and/or (3) via stimulation of the immune system. The aim of this review was to highlight the antiviral activity of LAB and substances they produce with antiviral activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / administration & dosage*
  • Bacteriocins / immunology*
  • Humans
  • Lactobacillaceae / genetics
  • Lactobacillaceae / immunology*
  • Probiotics / administration & dosage*
  • Virus Diseases / drug therapy*
  • Virus Diseases / immunology


  • Antiviral Agents
  • Bacteriocins