Effect of Erythrinamu lungu on anxiety during extraction of third molars

Med Oral Patol Oral Cir Bucal. 2014 Sep 1;19(5):e518-24. doi: 10.4317/medoral.19511.


Objectives: The aim of the present study was to evaluate the effect of Erythrinamu lungu on the control of dental anxiety in patients who had under gone bilateral extraction of asymptomatic, impacted mandibular third molars.

Material and methods: In a randomized, double-blind, crossover study, 30 healthy volunteers (5 men and 25 women, over 18 years of age), received either 500mg of E.mulungu (MulunguMatusa®) or 500 mg of placebo, p.o., one hour before surgical procedure. The level ofanxiety was assessed through questionnaire sand physical parameters, such as blood pressure, heart rate andoxygen saturation. Data were analyzed by Chi-square test, ANOVA (Tukey test) and Friedman with significance level of 5%.

Results: A higher preference (Chi-square, p = 0.0062) for E. mulungu was observed for both genders. Volunteers with higher anxiety levels tended to to prefer E. mulungu. No statistically significant differences were verified in blood pressure (one-way ANOVA, p = 0.1259), heart rate (Friedman, p> 0.05) and oxygen saturation (Friedman, p = 0.7664) among periods and types of treatments.

Conclusions: E. mulungu showed an anxiolytic effect without significant changes in physiological parameters. It could be considered as an alternative to control the anxiety in adult patients undergoing mandibular thirdmolars surgery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Cross-Over Studies
  • Dental Anxiety / prevention & control*
  • Double-Blind Method
  • Erythrina*
  • Female
  • Humans
  • Male
  • Molar, Third / surgery*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Tooth, Impacted / surgery*
  • Young Adult


  • Plant Extracts