Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation

Stem Cell Res. 2014 Nov;13(3 Pt B):571-81. doi: 10.1016/j.scr.2014.04.010. Epub 2014 May 6.


The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Heart / physiopathology*
  • Heart Diseases / enzymology*
  • Heart Diseases / genetics
  • Heart Diseases / metabolism
  • Heart Diseases / physiopathology
  • Heart Diseases / therapy
  • Humans
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / enzymology*
  • Myocytes, Cardiac / metabolism
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Regeneration*
  • Rejuvenation*
  • Signal Transduction
  • Transcription Factors


  • Adaptor Proteins, Signal Transducing
  • Phosphoproteins
  • Transcription Factors
  • YAP1 (Yes-associated) protein, human
  • Hippo protein, human
  • Protein-Serine-Threonine Kinases