Intracellular drug concentration and disposition--the missing link?

Methods. 2014 Jul 1;68(2):283-5. doi: 10.1016/j.ymeth.2014.05.009. Epub 2014 Jun 2.


Improved understanding of the concentration of a potential drug molecule at the site of action in physiologically relevant cells or tissues has emerged as a key challenge in the early stages of drug discovery. Improved ability to carry out such studies with label-free methodology has the potential to improve understanding of drug uptake and trafficking and thus contribute to the reduction of rates of attrition in drug discovery.

MeSH terms

  • Cytoplasm / drug effects*
  • Drug Discovery / methods*
  • Humans
  • Permeability / drug effects