Performance of a ⁶²Zn/⁶²Cu microgenerator in kit-based synthesis and delivery of [⁶²Cu]Cu-ETS for PET perfusion imaging

Appl Radiat Isot. 2014 Sep:91:38-43. doi: 10.1016/j.apradiso.2014.05.006. Epub 2014 May 22.


The performance of a commercially produced (62)Zn/(62)Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [(62)Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23 GBq (62)Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [(62)Cu]Cu-ETS (672±172 MBq) were delivered without difficulty. (62)Cu elution yields were high (approximately 90%), accompanied by extremely low (62)Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The (62)Zn/(62)Cu microgenerator was a dependable source of short-lived positron-emitting (62)Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [(62)Cu]Cu-ETS for PET perfusion imaging.

Keywords: (62)Zn/(62)Cu generator; PET radiopharmaceuticals; Tumor perfusion; [(62)Cu]Cu–ETS (copper(II) ethylglyoxal bis(thiosemicarbazone)).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper Radioisotopes / chemistry*
  • Head and Neck Neoplasms / diagnostic imaging
  • Humans
  • Kidney Neoplasms / diagnostic imaging
  • Organometallic Compounds / chemical synthesis*
  • Perfusion Imaging / methods*
  • Positron-Emission Tomography / methods
  • Radionuclide Generators / instrumentation*
  • Radiopharmaceuticals / chemical synthesis*
  • Thiosemicarbazones / chemical synthesis*
  • Zinc Radioisotopes / chemistry*


  • Copper Radioisotopes
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Thiosemicarbazones
  • Zinc Radioisotopes
  • ethylglyoxal bis(thiosemicarbazonato)copper(II)